Nature hosts an impressive array of chemical structures, proteins, and pathways that humanity has leveraged to make medicines, solvents, materials, and fuels. Advances in synthetic biology have dramatically reduced the cost of DNA synthesis, and enabled rapid prototyping and screening across a wide range of useful hosts. These synthetic tools have advanced the complexity of questions that can be asked and supported the development of systems biology models that more accurately predict phenotypes and facilitate design. Chemical and biological engineers are now using these tools and the knowledge gained with them to tackle Grand Challenges facing society – such as the need for new medicines to fight disease and prevent pandemics, the need for new technologies to improve the sustainability of our industries and address climate change, and the barriers preventing expansion of modern biomanufacturing across the world. The Biochemical and Molecular Engineering conference series brings together researchers from across engineering disciplines and the natural sciences to discuss recent progress in this broad field, network with experts across a wide range of specialties, and brainstorm new approaches to address global challenges facing biotechnology and society at large. This will be the twenty third edition of a conference series dating back to the dawn of the recombinant DNA era. This year the steering committee is thrilled to hold the meeting in Ireland – an emerging hub for biotechnology and biopharma, where we aim to expand our network and form a bridge between North American and European biotech. We hope you will consider joining us for a week of fun, vigorous scientific discourse in the friendly atmosphere of Dublin, Ireland. Please spread the word to your colleagues, particularly your younger colleagues, so the 2024 meeting can add to the long list of successful meetings in this series.